- Name : AZIMAHTOL HAWARIAH BT. LOPE PIHIE
- Qualifications :
Ijazah |
Bidang |
Tahun |
Instituisi |
BSc. (Honours)
2nd Upper |
Biologi
|
1976 |
Universiti Kebangsaan
Malaysia, MALAYSIA |
MSc.
|
Biokimia Pembiakan |
1978 |
University of Strathclyde,
Glasgow, UK |
PhD
|
Biokimia Klinik |
1985 |
University of Glasgow,
Scotland, UK |
- Specialisation :
Clinical Biochemistry
Clinical Endocrinology
Cancer Cell Biology
Medicinal Plants
- Areas of Research :
1. Development of SPD as anticancer drug
2. Evaluation of therapeutic and Toxic potential of natural product
3. Semiscale production of SPD through bioreactor propagation for Clinical trial
4. Pharmacological and Toxicological Evaluation of Extracts from Centella asiatica and Eurycoma longifolia Jack.
5. Identification of goniothalamin-targeted proteins and goniothalamin-induced proteins
6. Antiviral activity of selected Malaysia medicinal plants
7. Development of immunological-based thymidine kinase (TK) assay system as a tumor marker
8. Further studies of styrylpyrone derivative (SPD)
9. Development of cosmeceutical and phytopharmaceutical products from Curcuma xanthorriza (Temu Lawak) and Zingiber Zerumbet (Lempoyang).
10. Pharmacological and toxicological evaluation of new isolated bioactive compounds from Hydnophytum formicarium Jack (Rubiaceae)
- Current Projects and Grants :
1. Development of Cosmeceuticals and Pharmaceuticals from Zingiber zerumbet Smith and Curcuma xanthorrhiza. [06-02-02-001 BTK/ER/015(3a)]
2. Further studies of styrylpyrone derivative (SPD). [06-02-02-0013/PR000207-04]
3. Development of an immunological based assay system for tyhmidine kinase as a tumor marker. [06-02-02-0012/PR0002-07-03]
4. Anticancer and aphrodisiac properties of Eurycoma longifolia Jack [33-00-90-173]
- Selected Publications :
-
Rafidah Husen, Azimahtol Hawariah L.P. & Meenakshii Nallappan. 2004. Screening for antihyperglycaemic activity in several local herbs of Malaysia. Journal of Ethnopharmacology 95: 205–208
-
Lee, T.C.A., Azimahtol, H.L.P.
& Tan, A.N. 2003. Styrylpyrone Derivative (SPD) Induces Apoptosis
in a Caspase-7-dependent Manner in the Human Breast Cancer Cell Line
MCF-7. Cancer Cell International Vol 3: 16.
-
Alvin Lee, T.C. & Azimahtol Hawariah, L.P.
2003. Styrylpyrone Derivative (SPD) Induces Apoptosis through the
Up-regulation of Bax in the Human Breast Cancer Cell Line MCF-7. Journal of Biochemistry and Molecular Biology. Vol 36(3): 269-274.
-
Meenakshii, N., Lee, A., Azimahtol Hawariah, L. P.
and Hasidah, S. 2000. Increase levels of apoptosis correlate with p53
protein accumulation in response to styrylpyrone derivative (SPD)
treatment of the “Huggins tumor”. Journal of Malaysian Applied Biology,
Vol. 29(1&2): 121-126
-
Meenakshi, N., Teoh, P. L., Azimahtol Hawariah, L. P.
and Hasidah, M. S. Styrylpyrone Derivative (SPD) induced apoptosis in
ovarian cancer cells correlates with down-regulation of BCL-2 and MAPK
but up-regulation of BAX without alteration of p53 and c-JUN protein
level. Journal Tropical Medicinal Plant, Vol.1(Dec 2000): 1-5.
-
Seri Chempaka M. Y., Azimahtol Hawariah L. P.,
Halimah A. S. and Hasidah. M. S. 2000. An antitumor-Stylrylpyrone
Derivative (SPD) lowers serum cholesterol levels and atherosclerotic
lesions in hypercholesterolemic rats, Malaysian Applied Biology, 28(1 &2), 131-136.
-
Teoh, P. L. and Azimahtol Hawariah L. P. 2000. Effects of goniothalamin of bcl-2 and bax genes in human ovarian carcinoma cell line, CaOV-3, Malaysian Applied Biology, 28(1 &2), 113-118.
-
Azimahtol Hawariah L. P.,
Stanslas, J. and Laily, D. 1998. Non-steroid receptor mediated
antiproliferative activity of Styrylpyrone Derivative (SPD) in human
breast cancer cell lines. Anticancer Research, 18(2): 1739-1744.
-
Azimahtol Hawariah L. P.
and Stanlas J. 1998. Antagonistic effects of Styrylpyrone Derivative
(SPD) on 7, 12, dimethylbenzanthracene-induced rat mammary tumors. In vivo, 12(4): 403-410.
-
Azimahtol Hawariah L. P.
and Stanlas J. 1998. In vitro response of human breast cancer cell
lines to the growth-inhibitory effects of Styrylpyrone Derivative (SPD)
and assesment of its antiestrogenicity. Anticancer research, 18(6): 4383-4386.
Books
· Azimahtol Hawariah L. P. 1999.
A Gift of Biodiversity; Some Anticancer Drugs Developed From Natural
Product. In. Traditional and Alternative Medicine in Contemporary
Healthcare. Institute Medical Research/WHO Kuala Lumpur . 27-30.
· Azimahtol Hawariah, L.P. 1998: Understanding Cancer, Universiti Kebangsaan Malaysia Publisher, Bangi, Malaysia (ISBN 967-94240-4-9) pp 164.
· Azimahtol Hawariah, L.P. 1998: Hormon and Cancer, Universiti Putra Malaysia Publisher. (ISBN 983-9319-33-7) pp 56.
· Azimahtol Hawariah, L.P. 1998: Prostate Cancer, Universiti Putra Malaysia Publisher. (ISBN 983- 9319-36-1) pp 57.
· Azimahtol Hawariah, L.P. 1998: Breast Cancer, Universiti Putra Malaysia Publisher. (ISBN 983- 9319-34-5) pp 76.
· Azimahtol Hawariah, L.P. 1998: Ovarian Cancer, Universiti Putra Malaysia Publisher, (ISBN 983- 9319-37-X) pp 60.
· Azimahtol Hawariah, L.P. 1998: Uterus Cancer, Universiti Putra Malaysia Publisher, (ISBN 983- 9319-35-3) pp 56.
· Azimahtol Hawariah, L.P. 1998: Cervical Cancer, Universiti Putra Malaysia Publisher, (ISBN 983- 9319-38-8) pp 49.
· Che Jah Mohammad & Azimahtol Hawariah, L.P. 1998: Basic Biology and Biochemistry 1 Universiti Kebangsaan Malaysia Publisher. (ISBN 983-93192-8-0) pp 158.
- Contact Information :
- Address
SCHOOL OF BIOSCIENCES & BIOTECHNOLOGY
FACULTY OF SCIENCE & TECHNOLOGY
Universiti Kebangsaan Malaysia 43600 UKM Bangi Selangor Malaysia
- Phone Number
- Fax Number
- E-mail
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